American Journal of Neuroradiology, Vol 12, Issue 2 371-374, Copyright © 1991 by American Society of Neuroradiology
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MR measurement of intracranial CSF volume in 41 elderly normal volunteers
JA Malko, JC Hoffman Jr and RC Green
Department of Radiology, Emory University School of Medicine, Atlanta, GA 30322.
A noninvasive nonplanimetric MR protocol was used to measure the total intracranial CSF volume in 41 normal subjects, aged 60-84 years, who were intensively screened to eliminate CNS disease. The protocol entailed application of MR imaging data acquired with a spin-echo sequence in a single thick slice encompassing the head. The results show a strong correlation between increased intracranial CSF volume and increasing age, and a weaker correlation between increased intracranial CSF volume and increasing total intracranial volume. The possibility of employing a CSF volume measurement as a reflection of brain atrophy to help diagnose dementia is discussed.
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