American Journal of Neuroradiology, Vol 17, Issue 10 1901-1906, Copyright © 1996 by American Society of Neuroradiology
ARTICLES |
Embolization with cellulose porous beads, II: Clinical trial
J Hamada, Y Kai, S Nagahiro, N Hashimoto, H Iwata and Y Ushio
Department of Neurosurgery, Kumamoto University Medical School, Japan.
PURPOSE: To evaluate the clinical applicability of cellulose porous beads (CPBs) as an embolic material for permanent vascular occlusion. METHODS: Embolization with CPBs was performed in 16 patients, six with meningioma of the sphenoid wing, two with meningioma of the falx, three with meningioma of the tentorium, two with dural arteriovenous fistula, one with paraganglioma, and two with spinal arteriovenous malformation. Surgical specimens were examined histologically. RESULTS: No complications were encountered in any of the 16 patients. Angiograms obtained after embolization showed satisfactory vascular stasis in all cases. Histologic examination of surgical specimens disclosed that vessels having approximately the same caliber as the CPB particles were occluded without stretching of the vessel wall. Larger vessels were occluded by aggregates of many particles, which left no open spaces. Although a few inflammatory cells were seen in the thrombosed vessels, inflammation evoked by CPB was mild and did not extend to either the vessel wall or to surrounding tissues. CONCLUSION: CPBs were easy to inject through microcatheters, traveled to distal sites, and produced homogeneous and peripheral embolization without inflammatory changes different from other embolic materials. CPBs are a good embolic material for permanent occlusion in the clinical setting.
This article has been cited by other articles:
 |
|
 |
|
  Y. Kai, J.-I. Hamada, M. Morioka, S. Yano, H. Nakamura, K. Makino, T. Mizuno, H. Takeshima, and J.-I. Kuratsu Clinical evaluation of cellulose porous beads for the therapeutic embolization of meningiomas. AJNR Am. J. Neuroradiol., May 1, 2006; 27(5): 1146 - 1150. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kai, J.-i. Hamada, M. Morioka, T. Todaka, T. Mizuno, and Y. Ushio Pre- and Post-Treatment MR Imaging and Single Photon Emission CT in Patients with Dural Arteriovenous Fistulas and Retrograde Leptomeningeal Venous Drainage AJNR Am. J. Neuroradiol., April 1, 2003; 24(4): 619 - 625. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kai, J.-i. Hamada, M. Morioka, S. Yano, T. Todaka, and Y. Ushio Appropriate Interval between Embolization and Surgery in Patients with Meningioma AJNR Am. J. Neuroradiol., January 1, 2002; 23(1): 139 - 142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kai, J.-i. Hamada, M. Morioka, T. Todaka, S. Hasegawa, and Y. Ushio The Utility of the Microcrystalline Cellulose Sphere as a Particulate Embolic Agent:An Experimental Study AJNR Am. J. Neuroradiol., June 1, 2000; 21(6): 1160 - 1163. [Abstract] [Full Text]
|
|
|
|
 |
|
 Y. P. Gobin, F. Viñuela, H. V. Vinters, C. Ji, and K. Chow Embolization with Radiopaque Microbeads of Polyacrylonitrile Hydrogel: Evaluation in Swine1 Radiology, January 1, 2000; 214(1): 113 - 119. [Abstract] [Full Text]
|
|