American Journal of Neuroradiology, Vol 17, Issue 6 1041-1049, Copyright © 1996 by American Society of Neuroradiology
ARTICLES |
Multiple sclerosis lesions: relationship between MR enhancement pattern and magnetization transfer effect
JR Petrella, RI Grossman, JC McGowan, G Campbell and JA Cohen
Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia 19104, USA.
PURPOSE: To investigate the relationship between the enhancement pattern of a multiple sclerosis lesion and its magnetization transfer effect. METHODS: Fifty-four lesions were chosen from 29 patients with multiple sclerosis on the basis of enhancement pattern on contrast- enhanced T1-weighted MR images. They included 14 homogeneously enhancing lesions, 26 nonenhancing lesions, and 14 ring-enhancing lesions. Magnetization transfer ratios of the homogeneously enhancing lesions, nonenhancing lesions, and central portion of the ring- enhancing lesions were measured. Means were calculated and compared. RESULTS: The magnetization transfer ratios for homogeneously enhancing lesions were higher (mean, 32.2%; SD, 3.4%) than those for nonenhancing lesions (mean 29.4%; SD, 4.3%) and for the central portion of ring- enhancing lesions (mean, 24.5%; SD, 4.0%). Significant differences were found between the ring-enhancing lesions and the homogeneously enhancing lesions and between the ring-enhancing lesions and the nonenhancing lesions. CONCLUSION: We found a relationship between decreased magnetization transfer ratios and those enhancement patterns in which myelin is known to be decreased histopathologically. Thus, use of the magnetization transfer technique may increase the specificity of MR imaging in assessing the extent of residual myelination in multiple sclerosis lesions.
This article has been cited by other articles:
 |
|
 |
|
  Y. Ge Multiple Sclerosis: The Role of MR Imaging AJNR Am. J. Neuroradiol., June 1, 2006; 27(6): 1165 - 1176. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Symms, H R Jager, K Schmierer, and T A Yousry A review of structural magnetic resonance neuroimaging J. Neurol. Neurosurg. Psychiatry, September 1, 2004; 75(9): 1235 - 1244. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Cotton, H. L. Weiner, F. A. Jolesz, and C. R.G. Guttmann MRI contrast uptake in new lesions in relapsing-remitting MS followed at weekly intervals Neurology, February 25, 2003; 60(4): 640 - 646. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K Morgen, N O Jeffries, R Stone, R Martin, N D Richert, J A Frank, and H F McFarland Ring-enhancement in multiple sclerosis: marker of disease severity Multiple Sclerosis, June 1, 2001; 7(3): 167 - 167. [Abstract] [PDF]
|
|
|
|
|
|
J. He, R. I. Grossman, Y. Ge, and L. J. Mannon Enhancing Patterns in Multiple Sclerosis: Evolution and Persistence AJNR Am. J. Neuroradiol., April 1, 2001; 22(4): 664 - 669. [Abstract] [Full Text]
|
|
|
|
|
|
N D Richert, J L Ostuni, C N Bash, T P Leist, H F McFarland, and J A Frank Interferon beta-1b and intravenous methylprednisolone promote lesion recovery in multiple sclerosis Multiple Sclerosis, February 1, 2001; 7(1): 49 - 58. [Abstract] [PDF]
|
|
|
|
|
|
M Filippi Enhanced magnetic resonance imaging in multiple sclerosis Multiple Sclerosis, October 1, 2000; 6(5): 320 - 326. [Abstract] [PDF]
|
|
|
|
|
|
T L Luks, D E Goodkin, S J Nelson, S Majumdar, P Bacchetti, D Portnoy, and R Sloan A longitudinal study of ventricular volume in early relapsing-remitting multiple sclerosis Multiple Sclerosis, October 1, 2000; 6(5): 332 - 337. [Abstract] [PDF]
|
|
|
|
 |
|
 G. B. Pike, N. De Stefano, S. Narayanan, K. J. Worsley, D. Pelletier, G. S. Francis, J. P. Antel, and D. L. Arnold Multiple Sclerosis: Magnetization Transfer MR Imaging of White Matter before Lesion Appearance on T2-weighted Images Radiology, June 1, 2000; 215(3): 824 - 830. [Abstract] [Full Text]
|
|
|
|
|
|
S. Roychowdhury, J. A. Maldjian, and R. I. Grossman Multiple Sclerosis: Comparison of Trace Apparent Diffusion Coefficients with MR Enhancement Pattern of Lesions AJNR Am. J. Neuroradiol., May 1, 2000; 21(5): 869 - 874. [Abstract] [Full Text]
|
|
|
|
|
|
J. C. McGowan, J. H. Yang, R. C. Plotkin, R. I. Grossman, E. M. Umile, K. M. Cecil, and L. J. Bagley Magnetization Transfer Imaging in the Detection of Injury Associated with Mild Head Trauma AJNR Am. J. Neuroradiol., May 1, 2000; 21(5): 875 - 880. [Abstract] [Full Text]
|
|
|
|
|
|
M. Cercignani, G. Iannucci, M. A. Rocca, G. Comi, M. A. Horsfield, and M. Filippi Pathologic damage in MS assessed by diffusion-weighted and magnetization transfer MRI Neurology, March 14, 2000; 54(5): 1139 - 1144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Rovira, J. Alonso, G. Cucurella, C. Nos, M. Tintoré, S. Pedraza, J. Rio, and X. Montalban Evolution of Multiple Sclerosis Lesions on Serial Contrast-Enhanced T1-Weighted and Magnetization-Transfer MR Images AJNR Am. J. Neuroradiol., November 1, 1999; 20(10): 1939 - 1945. [Abstract] [Full Text]
|
|
|
|
|
|
G. Pike, de Stefano, Narayanan, G. Francis, J. Antel, and D. Arnold Combined Magnetization Transfer and Proton Spectroscopic Imaging in the Assessment of Pathologic Brain Lesions in Multiple AJNR Am. J. Neuroradiol., May 1, 1999; 20(5): 829 - 837. [Abstract] [Full Text]
|
|
|
|
|
|
J. L. Ostuni, N. D. Richert, B. K. Lewis, and J. A. Frank Characterization of Differences between Multiple Sclerosis and Normal Brain: A Global Magnetization Transfer Application AJNR Am. J. Neuroradiol., March 1, 1999; 20(3): 501 - 507. [Abstract] [Full Text]
|
|
|
|
|
|
J. Dehmeshki, M. A. Van Buchem, G. P. T. Bosma, T. W. J. Huizinga, and P. S. Tofts Systemic Lupus Erythematosus: Diagnostic Application of Magnetization Transfer Ratio Histograms in Patients with Neuropsychiatric Symptoms—Initial Results Radiology, March 1, 2002; 222(3): 722 - 728. [Abstract] [Full Text] [PDF]
|
|