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AJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 20:213-216 (2 1999)
© 1999 American Society of Neuroradiology

ARTICLE

Early and Delayed MR and PET Changes after Selective Temporomesial Radiosurgery in Mesial Temporal Lobe Epilepsy^,

Jean Regis^,a, Franck Semah^a, R. Nick Bryan^a, Olivier Levrier^a, Marc Rey^a, Yves Samson^a and Jean-Claude Peragut^a

^a From the Departments of Stereotactic and Functional Neurosurgery (J.R., J.C.P.), Neuroradiology (O.L.), and Neurophysiology (M.R.), La Timone Hospital, Marseille, France; Inserm U 334, Service Hospitalier F. Joliot, CEA, Orsay, France (F.S., Y.S.); the Department of Neurology, La Salpêtrière Hospital, Paris, France (F.S., Y.S.); and the Department of Radiology, National Institutes of Health, Baltimore, MD (R.N.B.).

Summary: We report a patient with medically refractory mesial temporal lobe epilepsy treated by gamma knife radiosurgery. In lieu of a microsurgical procedure, an entorhinoamygdalohippocampectomy was performed with a gamma knife and low marginal doses (25 Gy). The clinical and imaging studies, including CT, MR imaging, ¹⁸F-fluorodeoxyglucose positron emission tomography (FDG-PET), and long-term follow-up MR examinations, are reported. The patient has been seizure-free since the day of treatment, with no clinical complications. MR studies accurately depicted the effect on the target structures and the transient secondary changes around them. FDG-PET scans showed decreased metabolism after gamma knife surgery throughout the anteromesial part of the epileptogenic temporal lobe. This metabolic decrease was reversible in the lateral temporal cortex. Our case suggests that gamma knife surgery is a promising tool for use as a minimally invasive approach to the treatment of epilepsy.

This article has been cited by other articles:

				F. Bartolomei, M. Hayashi, M. Tamura, M. Rey, C. Fischer, P. Chauvel, and J. Regis Long-term efficacy of gamma knife radiosurgery in mesial temporal lobe epilepsy Neurology, May 6, 2008; 70(19): 1658 - 1663. [Abstract] [Full Text] [PDF]

				M. Quigg and N. M. Barbaro Stereotactic Radiosurgery for Treatment of Epilepsy Arch Neurol, February 1, 2008; 65(2): 177 - 183. [Abstract] [Full Text] [PDF]