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American Journal of Neuroradiology 20:1249-1251 (8 1999)
© 1999 American Society of Neuroradiology

ARTICLE

Regional Cerebral Glucose Metabolism and Blood Flow in a Patient with Marchiafava-Bignami Disease

Kazunari Ishiia, Yoshitaka Ikejiria, Masahiro Sasakia, Hajime Kitagakia and Etsuro Moria

a From the Division of Neuroimaging Research (K.I., M.S., H.K.) and Clinical Neurosciences (Y.I., E.M.), Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan.

Summary: We report functional neuroimaging studies of a 54-year-old man with Marchiafava-Bignami disease (MBD). Glucose metabolic images obtained by [18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography showed diffusely reduced whole brain metabolism and strongly decreased metabolism in the frontal and parietal lobes, orbital gyrus, and thalamus. Cerebral perfusion images showed a similarly decreased radioactivity pattern as the metabolic images. Functional neuroimages would be useful for understanding the pathophysiologic processes of MBD.




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