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American Journal of Neuroradiology 21:1853-1856 (11 2000)
© 2000 American Society of Neuroradiology

ARTICLE

Magnetization Transfer Ratio Is Unable to Lateralize Epileptic Foci in Patients with Temporal Lobe Epilepsy

Li Min Lia, Sridar Narayanana, Gilbert Bruce Pikea, Frederick Andermanna, François Dubeaua and Douglas L. Arnolda,b

a From the Department of Neurology and Neurosurgery, McGill University and the Montreal Neurological Institute and Hospital, Montreal, Quebec, Canada.
b Address reprint requests to Douglas L. Arnold, MD, Montreal Neurological Hospital and Institute, 3801 University Street, Montreal, Quebec, Canada H3A 2B4.

BACKGROUND AND PURPOSE: A preliminary report suggested that magnetization transfer ratio (MTR) was useful to lateralize epileptic foci in patients with refractory temporal lobe epilepsy (TLE). We attempted to confirm this finding in a larger group by investigating the relationship between MTR of mesial temporal structures and seizure lateralization in patients with refractory TLE.

METHODS: We compared the MTR of amygdalae and hippocampi of 10 patients with unilateral TLE to values obtained from 10 healthy control participants.

RESULTS: Three of 10 patients with TLE had MTR values that were 2 SD below the normal mean; the MTR abnormality was concordant with electroclinical lateralization in only one of the three.

CONCLUSION: We conclude that MTR measurements of amygdalae and hippocampi are not useful for lateralization of TLE.




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Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X