American Journal of Neuroradiology 25:39-51, January 2004
© 2004 American Society of Neuroradiology
INTERVENTIONAL
Cerebral Aneurysm Multicenter European Onyx (CAMEO) Trial: Results of a Prospective Observational Study in 20 European Centers
a Neurovascular Research Unit, Radcliffe Infirmary, Oxford, UK
b Hacettepe University, Ankara, Turkey
c Uppsala University, Uppsala, Sweden
Address correspondence to Andrew J. Molyneux, Neurovascular Research Unit, Radcliffe Infirmary, Oxford, OX2 6HE, UK
BACKGROUND AND PURPOSE: This study was designed to investigate the safety and efficacy of the Onyx liquid embolic system in treating a selected population of patients with intracranial aneurysms that presented difficulties for surgical or endovascular alternatives.
METHODS: A prospective observational study was conducted in 20 European centers enrolling a consecutive series of 119 patients with 123 aneurysms judged suitable for Onyx treatment. The series consists of findings collected in 97 of 119 patients with 100 of 123 aneurysms, because one center declined to provide data to the study sponsor or allow outside audit. Clinical and angiographic outcomes were recorded at discharge, 3 months, and 12 months. All adverse events and re-treatments were recorded. Seventy-nine aneurysms were large or giant.
RESULTS: Twelve-month follow-up angiography findings were available for 71 aneurysms. This angiographic follow-up showed complete occlusion in 56 (79%) aneurysms, subtotal occlusion in nine (13%), and incomplete occlusion in six (8%). Procedure- or device-related permanent neurologic morbidity at final follow-up was present in eight of 97 patients. Seven patients died: two deaths were procedure related; one, disease related; and four, unrelated causes. Seventy-five of the 82 patients alive and with follow-up at 12 months were at Rankin 2 or better status. Delayed occlusion of the parent vessel occurred in nine patients; delayed occlusion was asymptomatic in five and resulted in permanent neurologic deficit in two.
CONCLUSION: In selected patients with aneurysms that are unsuitable for coil treatment or in whom previous treatment has failed to occlude the aneurysm, Onyx treatment offers an endovascular alternative. Aneurysm occlusion rates are superior to reported rates of coil occlusion, and treatment morbidity is comparable to that of published prospective data on endovascular results for this subgroup of patients.
This article has been cited by other articles:
 |
|
 |
|
  M.-H. Li, Y.-Q. Zhu, C. Fang, W. Wang, P.-L. Zhang, Y.-S. Cheng, H.-Q. Tan, and J.-B. Wang The Feasibility and Efficacy of Treatment with a Willis Covered Stent in Recurrent Intracranial Aneurysms after Coiling AJNR Am. J. Neuroradiol., August 1, 2008; 29(7): 1395 - 1400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.J. van Rooij and M. Sluzewski Unruptured Large and Giant Carotid Artery Aneurysms Presenting with Cranial Nerve Palsy: Comparison of Clinical Recovery after Selective Aneurysm Coiling and Therapeutic Carotid Artery Occlusion AJNR Am. J. Neuroradiol., May 1, 2008; 29(5): 997 - 1002. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.H. Cekirge, K. Yavuz, S. Geyik, and I. Saatci HyperForm Balloon-Assisted Endovascular Neck Bypass Technique to Perform Balloon or Stent-Assisted Treatment of Cerebral Aneurysms AJNR Am. J. Neuroradiol., August 1, 2007; 28(7): 1388 - 1390. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Dudeck, O. Jordan, K.T. Hoffmann, A.F. Okuducu, I. Husmann, T. Kreuzer-Nagy, K. Tesmer, P. Podrabsky, H. Bruhn, J. Hilborn, et al. Embolization of experimental wide-necked aneurysms with iodine-containing polyvinyl alcohol solubilized in a low-angiotoxicity solvent. AJNR Am. J. Neuroradiol., October 1, 2006; 27(9): 1849 - 1855. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ozturk, I. Saatci, A.G. Pamuk, C. Erdogan, I. Akmangit, S. Geyik, and H.S. Cekirge Focal Increased Cortical Density in Immediate Postembolization CT Scans of Patients with Intracranial Aneurysms. AJNR Am. J. Neuroradiol., October 1, 2006; 27(9): 1866 - 1875. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Dudeck, O. Jordan, K.T. Hoffmann, A.F. Okuducu, K. Tesmer, T. Kreuzer-Nagy, D.A. Rufenacht, E. Doelker, and R. Felix Organic solvents as vehicles for precipitating liquid embolics: a comparative angiotoxicity study with superselective injections of Swine rete mirabile. AJNR Am. J. Neuroradiol., October 1, 2006; 27(9): 1900 - 1906. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Piotin, B. Daghman, C. Mounayer, L. Spelle, and J. Moret Ellipsoid approximation versus 3D rotational angiography in the volumetric assessment of intracranial aneurysms. AJNR Am. J. Neuroradiol., April 1, 2006; 27(4): 839 - 842. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. M. Kessler, C. Mounayer, M. Piotin, L. Spelle, J. R. Vanzin, and J. Moret The Use of Balloon-Expandable Stents in the Management of Intracranial Arterial Diseases: A 5-Year Single-Center Experience AJNR Am. J. Neuroradiol., October 1, 2005; 26(9): 2342 - 2348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Weber, R. Siekmann, B. Kis, and D. Kuehne Treatment and Follow-Up of 22 Unruptured Wide-Necked Intracranial Aneurysms of the Internal Carotid Artery with Onyx HD 500 AJNR Am. J. Neuroradiol., September 1, 2005; 26(8): 1909 - 1915. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Renowden Interventional neuroradiology J. Neurol. Neurosurg. Psychiatry, September 1, 2005; 76(suppl_3): iii48 - iii63. [Full Text] [PDF]
|
|
|
|
|
|
B. Lubicz, X. Leclerc, J.-Y. Gauvrit, J.-P. Lejeune, and J.-P. Pruvo Three-Dimensional Packing with Complex Orbit Coils for the Endovascular Treatment of Intracranial Aneurysms AJNR Am. J. Neuroradiol., June 1, 2005; 26(6): 1342 - 1348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Akpek, A. Arat, H. Morsi, R. P. Klucznick, C. M. Strother, and M. E. Mawad Self-Expandable Stent-Assisted Coiling of Wide-Necked Intracranial Aneurysms: A Single-Center Experience AJNR Am. J. Neuroradiol., May 1, 2005; 26(5): 1223 - 1231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Lubicz, M. Piotin, C. Mounayer, L. Spelle, and J. Moret Selective Endovascular Treatment of Intracranial Aneurysms with a Liquid Embolic: A Single-Center Experience in 39 Patients with 41 Aneurysms AJNR Am. J. Neuroradiol., April 1, 2005; 26(4): 885 - 893. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Pelz, T. Andersson, P. Lylyk, M. Negoro, and M. Soderman Stroke Review: Advances in Interventional Neuroradiology 2004 Stroke, February 1, 2005; 36(2): 211 - 214. [Full Text] [PDF]
|
|