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AJNR - American Journal of Neuroradiology

Published ahead of print on April 3, 2008
doi: 10.3174/ajnr.A0993

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American Journal of Neuroradiology 29:1140-1141, June-July 2008
© 2008 American Society of Neuroradiology

Technical Note
BRAIN

Inclusion or Exclusion of Intratumoral Vessels in Relative Cerebral Blood Volume Characterization in Low-Grade Gliomas: Does It Make a Difference?

G. Brasil Caseiras^a,b, J.S. Thornton^a, T. Yousry^a,b, C. Benton^b, J. Rees^b, A.D. Waldman^c and H.R. Jäger^a,b

^a Lysholm Department of Neuroradiology, University College London, London, United Kingdom
^b Institute of Neurology, University College London, London, United Kingdom
^c Department of Imaging, Charing Cross Hospital, London, United Kingdom

Please address correspondence to Gisele Brasil Caseiras, Queen Square, Box 65, London, United Kingdom WC1N 3BG; e-mail: g.brasil{at}ion.ucl.ac.uk

SUMMARY: We assessed the influence of inclusion (method 1) and exclusion (method 2) of intratumoral vessels when determining maximum relative cerebral blood volume (rCBVmax) in 3 types of low-grade gliomas (LGGs): astrocytomas, oligoastrocytomas, and oligodendrogliomas. Method 1 yielded significantly higher mean rCBVmax than method 2. However, only method 2 demonstrated a significant (P = .026) association between rCBVmax and membership of a differently ranked histologic category. Exclusion of intratumoral vessels appears, therefore, preferable when determining rCBVmax in LGGs.