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AJNR - American Journal of Neuroradiology

Publication Preview: Published July 30, 2009

American Journal of Neuroradiology 2009;30:1877.

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American Journal of Neuroradiology
DOI 10.3174/ajnr.A1723

BRAIN

CT Angiography Source Images Predict Final Infarct Extent in Patients with Basilar Artery Occlusion

V. Puetz, P.N. Sylaja, M.D. Hill, S.B. Coutts, I. Dzialowski, U. Becker, G. Gahn, R. von Kummer and A.M. Demchuk

From the Departments of Neurology (V.P., I.D., U.B., G.G.) and Neuroradiology (R.v.K.), Dresden University Stroke Center, University of Technology Dresden, Dresden, Germany; Calgary Stroke Program (V.P., P.N.S., M.D.H., S.B.C., I.D., A.M.D.), Department of Clinical Neurosciences, University of Calgary, Calgary, Canada; Ananthapuri Hospitals and Research Institute (P.N.S.), Thiruvananthapuram, India; and Department of Neurology (G.G.), Karlsruhe Community Hospital, Karlsruhe, Germany.

Please address correspondence to Volker Puetz, MD, University of Technology Dresden, Department of Neurology, Dresden University Stroke Center, Fetscherstr 74, 01307 Dresden, Germany; e-mail: volker.puetz{at}neuro.med.tu-dresden.de

BACKGROUND AND PURPOSE: The posterior circulation Acute Stroke Prognosis Early CT Score (pc-ASPECTS) is a 10-point grading system to quantify ischemic changes in the posterior circulation. We analyzed whether pc-ASPECTS on CT angiography (CTA) source images (CTASI) predicted the final infarct extent and hemorrhagic transformation (HT) rate in patients with basilar artery occlusion.

MATERIALS AND METHODS: A pc-ASPECTS score of 10 indicates absence of visible ischemic changes in the posterior circulation, and pc-ASPECTS score of 0 indicates ischemic changes in the midbrain, pons, and bilateral thalami, posterior circulation territories, and cerebellar hemispheres. We retrospectively studied patients with basilar artery occlusion on CTA within 24 hours from symptom onset. We applied pc-ASPECTS to noncontrast CT (NCCT), CTASI, and follow-up images by 3-reader-consensus and assessed HT on follow-up images. We calculated Spearman correlation coefficients and performed linear regression analysis. Final infarct extent and HT rates were compared across dichotomized CTASI pc-ASPECTS groups ( 8 vs < 8).

RESULTS: Among 43 patients, median (range) onset to CTA time was 5.0 hours (range, 0.7–24 hours). Pc-ASPECTS on CTASI (r = 0.75; P < .001) but not NCCT (r = 0.29; P = .063) correlated with pc-ASPECTS on follow-up scans. Linear regression demonstrated a significant positive relationship between pc-ASPECTS on CTASI and follow-up scans (R² = 0.58; P < 01). Median follow-up pc-ASPECTS was lower in patients with a CTASI pc-ASPECTS < 8 compared with patients with a CTASI pc-ASPECTS of 8 or more, respectively (P < .001). HT rates were 27.3% vs 9.5%, respectively (P = .24). None of 8 patients without thrombolysis had HT on follow-up scans.

CONCLUSIONS: The extent of hypoattenuation on CTASI predicts the final infarct extent in patients with basilar artery occlusion.