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AJNR - American Journal of Neuroradiology

Published ahead of print on April 22, 2009
doi: 10.3174/ajnr.A1542

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Neck Injury Is Critical to Elastase-Induced Aneurysm Model

K. Wang^a, Q. Huang^a, B. Hong^a, Y. Xu^a, W. Zhao^a, J. Chen^a, R. Zhao^a and J. Liu^a

^aFrom the Department of Neurosurgery, Changhai Hospital of Second Military Medical University, Shanghai, P.R. China.

View larger version (18K): [in this window] [in a new window]   Fig 1. Schematic of elastase-induced aneurysms in rabbits in groups 1 and 2. A temporary arcuate aneurysm clip is placed at the origin of the RCCA, indicating the inner edge of clip blade on the juncture of RCCA and right subclavian artery. LCCA indicates left common carotid artery.

View larger version (83K): [in this window] [in a new window]   Fig 2. Intravenous digital subtraction angiography in a rabbit from group 1. The aneurysm is stable at 3 weeks, 8 weeks, 4 months, and 6 months after surgery.

View larger version (118K): [in this window] [in a new window]   Fig 3. Histopathologic analysis of the right common carotid artery (RCCA) in group 1. A, The RCCA induced by elastase after 3 weeks, stained by ponceau/Victoria blue, becomes an aneurysm with intact elastin in the parent vessel and abrupt termination of the elastic lamina at the margins of aneurysm orifice (original magnification x40). B, Hematoxylin-eosin staining indicates a thin aneurysm wall, the absence of an inflammatory reaction, and marked loss of cellular elements (original magnification x200).